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KMID : 0369819920220040323
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Jorunal of Korean Pharmaceutical Sciences
1992 Volume.22 No. 4 p.323 ~ p.326
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Release of Cytarabine from Poly ( ε - carbobenzoxy L - lysine ) / Poly ( ethylene oxide ) / Poly ( ε - carbobenzoxy L - lysine ) Block Copolymer Microspheres
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조종수/Cho CS
권중근/조병욱/이강춘/성용길/Kwon JK/Jo BW/Lee KC/Sung YK
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Abstract
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Poly(ε?carbobenzoxyL?lysine)/poly(ethyleneoxide)/poly(ε?carbobenzoxyL?lysine) (LEL) block copolymers containing poly(ε?carbobenzoxyL?lysine) (PCLL) as the A component and poly(ethylene oxide) (PEO) as the B component were investigated as drug delivery matrix. PCLL homopolymer and LEL block copolymer microspheres containing anticancer drug, cytarabine, were prepared by a solvent evaporation process and the release patterns of cytarabine from the microspheres were investigated in vitro. The size of PCLL homopolymer and LEL block copolymer microspheres was ranged from 0.2μm to 1μm in diameter and the shape of the microspheres was almost round. The release pattern of cytarabine from the block copolymer microspheres was dependent on the mole % of PEO of the block copolymers.
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KEYWORD
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Copolymer, Poly(ε?carbobenzoxy L?lysine), Poly(ethylene oxide), Microspheres, Cytarabine, Drug release
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